The Daily "ECHO"

The Daily Echo: Adderall, Stimulants & Modafinil for ADHD: Short & Long-Term Effects with Andrew Huberman: May 30, 2023

May 30, 2023

In this episode, I explain how medications such as Adderall, Ritalin, Vyvanse and other stimulants work to increase focus and treat attention-deficit/hyperactivity disorder (ADHD). I explain the brain circuits involved in focus and the key roles dopamine and norepinephrine play in their regulation. Then I explain how stimulants such as Adderall and Vyvanse can increase focus and reduce hyperactivity in kids or adults with ADHD, and how and why Ritalin and other medications (e.g., Modafinil, Guanfacine) may work better for some. I explain the long-term effects of ADHD medications on height, cardiovascular health, hormones, predisposition to addiction and psychosis, and whether these treatments can be used and then stopped. I also discuss the immense individual variation in dosage sensitivity for these medications and the negative side-effects that occur from recreational use. This episode ought to benefit anyone with ADHD, their parents, those on ADHD medications or anyone curious about how these medications work. #HubermanLab Thank you to our sponsors AG1: Maui Nui Venison: ROKA: HVMN: InsideTracker: Momentous: The Brain Body Contract Social & Website Instagram: Twitter: Facebook: LinkedIn:… Website: Newsletter: Articles Cardiovascular Effects of ADHD Therapies: JACC Review Topic of the Week: Brain alterations in children/adolescents with ADHD revisited: A neuroimaging meta-analysis of 96 structural and functional studies: Impulsivity, Compulsivity, and Top-Down Cognitive Control: Dopaminergic System Dysfunction in Recreational Dexamphetamine Users: Modafinil enhances alerting-related brain activity in attention networks: Association of Intrinsic Brain Architecture With Changes in Attentional and Mood Symptoms During Development: Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine: Psychostimulants and Cognition: A Continuum of Behavioral and Cognitive Activation: Neural Correlates of Symptom Improvement Following Stimulant Treatment in Adults with Attention-Deficit/Hyperactivity Disorder: Long-term effects of stimulant exposure on cerebral blood flow response to methylphenidate and behavior in attention-deficit hyperactivity disorder: Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review: Pharmacologic treatment of attention deficit hyperactivity disorder in adults: A systematic review and network meta-analysis: Books Stahl’s Essential Psychopharmacology (4th Edition): Other Resources Controlling Your Dopamine For Motivation, Focus & Satisfaction:    • Controlling Your …   Leverage Dopamine to Overcome Procrastination & Optimize Effort:    • Leverage Dopamine…   ADHD & How Anyone Can Improve Their Focus:    • ADHD & How Anyone…   Timestamps 00:00:00 Stimulants & Attention-Deficient/Hyperactivity Disorder (ADHD) 00:03:21 Sponsors: Maui Nui, ROKA, HVMN 00:06:35 The Brain-Body Contract 00:07:22 Attention, Prefrontal Cortex & ADHD 00:16:27 Stimulants “Sympathomimetics” 00:21:29 Adderall, Dopamine & Norepinephrine 00:25:58 Sympathomimetics, Dopamine & Norepinephrine 00:31:05 Sponsor: AG1 00:32:20 Vyvanse is Timed-Release D-Amp 00:36:36 Ritalin, Concerta 00:40:10 Dopamine & “Noise Reduction”; Norepinephrine & “Signal Amplification” 00:45:28 ADHD: Focus, Hyperactivity & Impulsivity; Drug Selection & Dose 00:50:57 How do Stimulants ‘Calm’ ADHD? 00:54:48 Neuroplasticity & Neuromodulators 00:58:06 Kids, ADHD Diagnosis & Treatment; Predispose Addiction? 01:04:02 Sponsor: InsideTracker 01:05:12 ADHD Medications: Individuality, Doses, Tapering & Long-Term Use 01:13:28 Medication & Long-Term Effects: Height, Cardiovascular Risk, Alcohol 01:19:32 Cortisol & Hormones 01:27:45 Psychosis & Addiction; Methamphetamine 01:38:20 Recreational Use, Addiction & Psychosis; Habituation 01:42:30 Drug Holidays; Ritalin & Long-Term Effects 01:45:35 Modafinil, Armodafinil; Side-Effects 01:53:03 Guanfacine, Alcohol 01:58:03 ADHD Medications 02:00:26 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer:

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