The Daily Echo: How to Avoid Insulin Resistance and Why It’s Important..Dr Robert Lustig and Dr. Dom D’Agostino: July 24, 2025

Insulin resistance is when cells stop responding to insulin’s signal to uptake glucose. It’s a hallmark of prediabetes, Type 2 diabetes, and other forms of metabolic dysfunction, and it manifests as several chronic disease, ranging from Alzheimer’s to polycystic ovarian syndrome. Dr. Robert Lustig and Dr. Dominic D’Agostino discuss the importance of monitoring insulin levels, why a high or increasing insulin level is a problem, and how insulin resistance hinders weight management. Sign Up to Get Your Ultimate Guide to Glucose: https://levels.link/youtube?utm_campa…00:00 — Intro 01:44 — What is insulin? 04:43 — What is insulin resistance? 15:50 — There are three types of insulin resistance 36:03 — Weight management is not about calories in and calories out 44:00 — Adding more insulin to the equation of Type 2 diabetes isn’t necessarily the answer 49:31 — Insulin is a crucial biomarker to measure for metabolic health 52:11 — Insulin resistance is a hinderance to weight management 54:42 — The intake of too much leucine can lead to insulin resistance 1:00:22 — Fiber feeds the gut microbiome and is crucial for metabolic health 1:11:27 — Is intermittent fasting necessary? 👋 WHO WE ARE: Levels helps you see how food affects your health. With real-time, personalized data gathered through biosensors like continuous glucose monitors (CGM), you learn which diet and lifestyle choices improve your metabolic health so you can live a longer, fuller, healthier life. 🔗 LINKS: Transcripts & Show notes: https://www.levels.com/podcasts/209-w… Subscribe here on YouTube:    / @levels   Connect with Robert Lustig, MD, on Instagram:   / robertlustigmd   Connect with Robert Lustig, MD, on Twitter:   / robertlustigmd   Connect with Dominic D’Agostino, PhD, on Instagram:   / dominic.dagostino.kt   Connect with Dominic D’Agostino, PhD on Twitter:   / dominicdagosti2